Cannabis topicals act as lubricants that penetrate the surface layer of the skin. But their treatment goes much deeper. Cannabis topicals work by directly entering the bloodstream via the skin.Once in the bloodstream, they bind with different cannabinoid receptors in the endocannabinoid system. Within an hour, you’ll likely start to feel the effects of a topical. You may opt to use a full-spectrum cannabis product containing THC, CBD, and a range of terpenes (flavorful and aromatic compounds). You may also choose a pure CBD isolate product. Full-spectrum products do precisely what their name implies; they offer an infusion of every possible element the plant naturally provides.On the other hand, CBD isolate strips away other cannabinoids and loses some therapeutic properties.